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A Comparison of Parenterally and Orally Supplied Protein Hydrolysate for Utilization of the Nitrogen in Long Continued Feeding Experiments

Department of Nutrition of the Division of Development, E. R. Squibb and Sons, New Brunswick, N. J.

Dogs were depleted of protein reserves by the feeding of protein-free diets with and without the accompaniment of plasmapheresis. Repletion was carried out by parenteral infusion of casein hydrolysate for an extended period, followed by a like period of oral feeding of casein hydrolysate. During repletion the dogs showed no striking increments in body weight. Even though partial repletion had been effected by intravenous infusion of casein hydrolysate, the dogs retained more nitrogen via the oral route than via the parenteral route. The nitrogen retention coefficient of the dogs was 1.7. The gain in protein per kilogram of body weight per calorie of intake via the oral route is twofold the value obtained via the parenteral route in animals subjected to extensive depletion. More of the nitrogen retained via parenteral feeding was utilized for plasma protein regeneration than of that retained by oral feeding, although more total nitrogen was retained by the oral route of administration.

There appeared to be a difference in the utilization of administered nitrogen dependent upon the extent of depletion of the "protein reserves" of the experimental animal and the mode of administration of the hydrolysate. A possible explanation for this difference has been discussed.

² Present address: Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland.

Manuscript received 15 August 1949.