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Effect of Vitamins A and D on Resistance to Infection

(From the Departments of Vital Economics and Bacteriology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.)

1. Young white rats were inoculated by intraperitoneal injection of a standard suspension of organisms after 4, 6, 8 and 10 weeks on a vitamin A-free diet. Markedly decreased resistance to such infection, compared with controls receiving cod liver oil, was demonstrated before other signs of vitamin A deficiency appeared.

2. No such suscpetibility to similar inoculations was found in young rats on a diet deficient in vitamin D, compared to controls protected by irradiated ergosterol.