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Journal of Nutrition Vol. 39 No. 4 December 1949, pp. 579-590
Copyright © 1949 by American Society for Nutrition
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Succinylsulfathiazole and a Rat Growth Factor in Liver1

James Hazlitt Jones, Charles S. Rogers and Charles H. Stone, III

Departments of Biochemistry, School of Veterinary Medicine, and Physiological Chemistry, School of Medicine, University of Pennsylvania, Philadelphia

Young rats on a synthetic diet containing purified casein and all members of the vitamin B group except pteroylglutamic acid and vitamin B12 grew well. The addition of succinylsulfathiazole produced the usual results, namely, failure of growth, leukocytopenia with the granulocytes affected more than the other cells, and finally death.

The inclusion of pteroylglutamic acid in the succinylsulfathiazole diet corrected the blood dyscrasia and prevented the death of the animals but failed to restore growth completely. Increasing the amount of pteroylglutamic acid did not change the picture.

Animals given succinylsulfathiazole plus a crude liver extract had normal blood and grew at a rapid rate.

Doubling the amount of 2-methyl-1,4-naphthoquinone and of the dietary B vitamins except choline did not increase the growth of rats given succinylsulfathiazole and pteroylglutamic acid.

The subcutaneous injection of 0.02 ml of a purified antipernicious anemia liver preparation in rats on the latter regimen produced very good growth.

The probable relation of this growth factor found in liver to vitamin B12 is discussed.

1 Most of the data presented here were collected during 1946 and the first three months of 1947, but the completion of the experimental work and preparation of the manuscript were unavoidably delayed until recently.

Manuscript received 1 August 1949.




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