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Vitamin a Utilization Studies

II. The Utilization of Vitamin A Alcohol, Vitamin a Acetate and Vitamin a Natural Esters by the Rat

Research Laboratory, Collett-Week-Nibecker, Inc., South San Francisco, California

1. Vitamin A liver storage measurements were used as the criterion for determining the relative utilization by the rat of the alcohol, acetate and natural ester forms of vitamin A under various experimental conditions.

2. It was shown that the relative biological efficacy of the three forms of the vitamin, although administered at equivalent unit levels, was greatly affected by the nature and quantity of the diluent present in the vitamin A supplement. Experimental conditions were established under which the relative biological response produced by the natural ester form could be varied from 59 to 105% of that produced by comparable supplements of vitamin A alcohol. It was also demonstrated that variations in the biological utilization of vitamin A acetate under diverse experimental conditions are significantly different from those of vitamin A natural esters.