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Journal of Nutrition Vol. 39 No. 2 October 1949, pp. 159-165
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The Urinary Excretion of Pentose- and Phosphorus-Containing Complexes in Nutritional Muscular Dystrophy

A. S. Minot and Merwin Grimes1

Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee

Studies have been carried out on urines obtained from 6 young rabbits with muscular dystrophy produced by a dietary lack of vitamin E.

Control studies were negative. With the onset of signs of muscular dysfunction, pentose and readily hydrolyzable organically bound phosphate appeared simultaneously in the urine. The isolation and identification of pentose as an osazone and the liberation of bound phosphate by 7-minute hydrolysis with 1 N HCl was considered chemical evidence of the presence of pentose-phosphorus-containing complexes apparently identical with those reported in clinical cases of progressive muscular dystrophy.

1 Some of the data contributed to this paper by this author was also incorporated in a thesis submitted by him for partial fulfillment of the requirements for a degree of Master of Science from Vanderbilt University.

Manuscript received 20 June 1949.




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