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Experimental Rat Caries

III. The Effect of Bromide on Experimental Rat Caries

Four Figures

Harvard School of Dental Medicine, Boston, Massachusetts

1. The absence of caries previously observed in rats bred by mothers subsisting on a natural stock diet, as compared to the extensive caries produced in rats bred on a purified ration, cannot be attributed to the presence of bromine in the stock diet, because the addition of high doses of bromide to the purified ration, during tooth development, failed to provide caries protection.

2. The caries susceptibility observed in rats bred by mothers subsisting on a purified diet is not decreased but appears to be somewhat increased by the addition of bromide to the diet during the period of tooth development alone. The possibility is considered that bromine added to a purified ration may take the place of a factor more essential to the caries resistance of the developing teeth.

3. Caries could be reduced, however, when the bromide supplement was continued after eruption of the teeth. This seems to suggest that one and the same factor (at least when added to a purified diet) may be ineffective or unfavorable to the teeth during their development and still be favorable after tooth eruption.

4. It is suggested that more effective caries inhibitors may be found in food factors which exert a favorable action during tooth development as well as posteruptively.