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Urinary Pantothenate, Blood Glucose, and Inorganic Serum Phosphate in Patients with Metabolic Disorders Treated with Doses of Pantothenate¹

The Third (New York University) Medical Division, Bellevue Hospital, and the Metabolism Clinics of New York University College of Medicine, New York City

The daily excretion of pantothenic acid was studied in patients with diabetes, Addison's disease, cirrhosis of the liver, and chromophobic tumor of the pituitary. On a normal diet the excretion of pantothenic acid in all subjects varied from 2.6 to 8.6 mg per 24 hours. When calcium pantothenate was added to the diet the daily excretion rose so that at least 9% of the ingested pantothenate was excreted. When panthenol was the source of pantothenate, the excretion of pantothenic acid was still further increased. Insulin and glucose given intravenously did not affect the excretion of pantothenic acid in any of the patients studied. The blood levels of glucose and inorganic phosphate, determined following the intravenous administration of glucose or insulin, were not influenced by large daily doses of calcium pantothenate.

² Present address: Nutrition Laboratories, Hoffmann-LaRoche, Inc., Nutley, New Jersey.

Manuscript received 5 May 1949.