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Journal of Nutrition Vol. 38 No. 4 August 1949, pp. 535-542
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A Paradoxical Relationship between Serum Level and Liver Content of Vitamin A1

One Figure

R. F. Krause

Department of Biochemistry, College of Medicine, University of Vermont, Burlington

An examination was made of the relationship between serum level and liver content of vitamin A in normal rats and those under the influence of varying degrees of vitamin A depletion. The following points were observed:

(1) An inverse relationship existed between blood and liver levels of vitamin A in normal male and female rats and those depleted female animals whose liver content ranged as low as 600 I.U./total liver.
(2) When the total liver content fell below 600 I.U. in the males there was a parallelism between blood and liver levels.

1 This work was supported in part by grants from Merck and Co., Inc., Milbank Memorial Fund and National Vitamin Foundation, Inc.

Manuscript received 9 March 1949.




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