Journal of Nutrition

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Journal of Nutrition Vol. 38 No. 3 July 1949, pp. 361-368
Copyright © 1949 by American Society for Nutrition
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Studies on the Comparative Nutritive Value of Fats

XI. On the Possible Growth-Promoting Activity of {Delta}12-Octadecenoic Acid1

Harry J. Deuel, Jr., Samuel M. Greenberg, Evelyn E. Straub, Tomoko Fukui, Chester M. Gooding and Carl F. Brown

Department of Biochemistry and Nutrition, University of Southern California, Los Angeles and Bayonne Laboratory, The Best Foods, Inc.

1. No increase in growth over that obtained with the unsupplemented diets could be noted in rats fed diets containing cottonseed oil and supplemented with {Delta}12-trans-octadecenoic acid, a 1:1 mixture of {Delta}11- and {Delta}12-trans-octadecenoic acids, or a mixture of cis- and trans-{Delta}11- and {Delta}12-octadecenoic acids.
2. Identical growth was obtained whether the diets contained summer butterfat or cottonseed oil.
3. The tests further confirm the inactivity of vaccenic acid ({Delta}11-octadecenoic acid) as a dietary supplement.

1 This work was carried out under a research grant from The Best Foods, Inc. The authors wish to acknowledge the helpful advice of Professor Anton J. Carlson of the University of Chicago, Professor Arthur W. Thomas of Columbia University, and Dr. H. W. Vahlteich of The Best Foods, Inc., during the course of the experiments. Contribution number 210 from the Department of Biochemistry and Nutrition, University of Southern California.

Manuscript received 8 March 1949.




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