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Vitamin Studies in Middle-Aged and Old Individuals

III. Thiamine and Pyruvic Acid Blood Concentrations¹

Three Figures

Division of Gerontology, Washington University School of Medicine and The St. Louis City Infirmary Hospital, St. Louis, Missouri

An investigation was made of the concentrations of blood thiamine and pyruvic acid in 220 middle-aged and old individuals offered a diet adequate in vitamin B₁, and in 29 younger subjects. The average concentration of thiamine was 3.4 µg% (s.d. 1.1 µg%) and of pyruvic acid 1.1 mg% (s.d. 0.3 mg%). A slight tendency was noted for the thiamine value of blood to decrease with age (coefficient of correlation age/thiamine, — 0.20), whereas the pyruvic acid level showed no change with advancing years. No significant correlation was observed between the thiamine and pyruvic acid values in the same individuals (coefficient of correlation thiamine/pyruvic acid, — 0.14).

Manuscript received 5 March 1949.

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