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Influence of Thyroid on Utilization of Vitamin A

Pediatric Research Laboratory and Department of Biochemistry, Jewish Hospital of Brooklyn, Brooklyn, New York

Vitamin A storage in the liver of rats on a vitamin A free diet was highest in the thyroidectomized animals, intermediate in the thyroxine-treated animals and lowest in the controls.

Growth of the control rats was most marked and probably accounts for the lower stores of vitamin A during a period when only endogenous vitamin A was available to the animals. Thyroid activity, in this instance, was indirect, in that growth was greatest in the euthyroid state.

Higher stores of vitamin A were found in thyroidectomized as compared with thyroxine-treated animals after a period of depletion, although there was no statistically significant difference in the weight changes. However, this cannot be necessarily ascribed to a direct thyroid-vitamin A relationship.