QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chow, B. F. Articles by Biase, S. d. Search for Related Content PubMed Articles by Chow, B. F. Articles by Biase, S. d.

The Effect of Retention of Nitrogen in Casein or Lactalbumin Hydrolysates on the Regeneration of Plasma Proteins of Protein-depleted Dogs

Division of Protein Chemistry, The Squibb Institute for Medical Research, and Department of Nutrition, Division of Development, E. R. Squibb and Sons

Protein-depleted dogs were fed one level of casein hydrolysate. For comparison, three other groups of dogs were given different levels of lactalbumin hydrolysate so that the retained nitrogen was either greater, approximately equal to, or less than that in dogs receiving the casein hydrolysate. In addition, two other groups of dogs were administered the casein hydrolysate orally with the supplementation of 1 or 2% methionine, in order to increase the nitrogen retention to approximately that retained by the animals receiving the highest dosage of lactalbumin hydrolysate. The total nitrogen absorbed and the regeneration of various plasma protein components were determined quantitatively. The data demonstrated that the lactalbumin hydrolysate given at any one of the levels stimulated the production of albumin and led to a marked decrease in alpha globulins. On the other hand, casein hydrolysate favored the production of albumin and globulins even on supplementation with methionine, which increased the absorption of the casein hydrolysate nitrogen fed. The results, therefore, led to the conclusion that the difference in the plasma protein regeneration properties of the two protein hydrolysates is not due to the difference in the amount of absorbed nitrogen, but perhaps to the existence of an unidentified nutritional factor.

Manuscript received 15 January 1949.