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The Biological Value of Corn and Wheat Proteins in the Male Infant, with a Note on the Utilization of D-Tryptophan¹

Department of Pediatrics, New York University College of Medicine, and the Children's Medical Service, Bellevue Hospital, New York City

It has been found that the nitrogen retention and weight gain of infants maintained on a synthetic diet in which tryptophan- and lysine-supplemented commercial zein constituted the principal source of nitrogen were inferior, by reason of the poor digestibility of the zein, to those obtained on a casein diet fed at the same fluid, caloric distribution and nitrogen levels. A diet in which tryptophan- and lysine-reinforced corn gluten provided the major source of protein also proved to be nutritionally inadequate for the infant. In contrast, a lysine-enriched wheat gluten diet supported a nutritional state in the infant comparable to that afforded by an evaporated milk formula. Evidence, albeit inconclusive, is presented which suggests that the inclusion of D-tryptophan in the diet may have an untoward nutritional effect.

Manuscript received 9 February 1949.