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The Utilization of Nicotinic Acid by Pregnant Women¹

Two Figures

Department of Home Economics, University of Chicago, Chicago, Illinois

1. The dietary intake of nicotinic acid, the urinary excretion of the acid-hydrolyzable fraction and N¹-methylnicotinamide, and the response to a 50 mg test dose of nicotinamide, were studied on 7 primigravidae during each of the last 5 months of pregnancy. In addition, a study was made of the dietary intake of nicotinic acid and the urinary excretion of N¹-methylnicotinamide by 42 clinic subjects. The estimated intake of nicotinic acid, the urinary excretion of N¹-methylnicotinamide and the response to a 50 mg test dose of nicotinamide were observed on 12 non-pregnant women.

2. There was a constant level of excretion of the acidhydrolyzable fraction regardless of intake.

3. There was a statistically significant increase in the excretion of N¹-methylnicotinamide by the 5 primigravidae in group I on unsupplemented diets during the last trimester of pregnancy. This observation was confirmed by the data on the 14 primigravidae in group II.

4. The significance is discussed of the relation of the intake of nicotinic acid to the urinary excretion of N¹-methylnicotinamide and the percentage return of a 50 mg test dose of nicotinamide.

² Present address: Alabama Polytechnic Institute, Auburn, Alabama.

³ Present address: Chicago, Illinois.

Manuscript received 7 September 1948.

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