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Pantothenc Acid and Conjugation Reactions in Vivo

I. The Effect of Pantothenic Acid and Thiamine Deficiencies on the Ability of the Rat to Acetylate Sulfanilamide1

One Figure

Maurice E. Shils, Herbert M. Seligman and Leonard J. Goldwater

Division of Industrial Hygiene, School of Public Health, Columbia University, New York City

1. Rats maintained on a pantothenic acid-deficient diet excreted much smaller percentages of test doses of sulfanilamide in the acetylated form than did control animals.
2. Adrenal cortical extract had no influence on the reduced ability of pantothenic acid-deficient rats to acetylate sulfanilamide.
3. Thiamine deficiency did not affect the ability of male rats to acetylate sulfanilamide as indicated by urinary excretion values.

1 This work was supported by a grant from the National Vitamin Foundation. Preliminary studies were carried out with the assistance of a grant (RG 312c) from the U. S. Public Health Service.

Manuscript received 14 September 1948.




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Copyright © 1949 by American Society for Nutrition