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Phlorhizin Diabetes in Vitamin Deficiencies¹

Conversion of Protein to Glucose, and Serum Phosphatase, during Deficiencies of Thiamine, Riboflavin, and Pyridoxine

Edsel B. Ford Institute for Medical Research, Henry Ford Hospital, and Department of Chemistry, Wayne University, Detroit, Michigan

1. In dogs phlorhizinized during thiamine or riboflavin deficiencies of sufficient duration to produce the characteristic signs, formation of glucose from protein is not impaired. There is also no evidence that these deficiencies restrict utilization of glucose in the phlorhizinized animal.

2. In pyridoxine deficiency, the D:N ratios were quite low in one animal and somewhat low in another, and increased in both animals following administration of the missing vitamin. The maximum change corresponded to formation of 44% instead of 58% of glucose from protein.

3. In dogs receiving a carbohydrate-free diet containing 72.2% of casein, pyridoxine deficiency appeared rapidly, and thiamine deficiency in the usual time, following withdrawal of the corresponding vitamin.

4. The disturbances in the central nervous system sometimes seen in dogs during pyridoxine deficiency were observed in one animal in the absence of hypoglycemia or anemia. The supply of glucose and oxygen to the nervous system is thus presumably normal, though the possibility of interference with utilization cannot be excluded.

5. Serum alkaline phosphatase was elevated during all phlorhizin periods in which it was determined. The relation ship of this finding to changes in phosphatase observed in other forms of diabetes is discussed.

Manuscript received 29 July 1948.