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Journal of Nutrition Vol. 37 No. 1 January 1949, pp. 9-20
Copyright © 1949 by American Society for Nutrition
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Corneal Changes in the Rat with Deficiencies of Pantothenic Acid and of Pyridoxine1

Nine Figures

Lester L. Bowles, W. Knowlton Hall, V. P. Sydenstricker and Charles W. Hock

Departments of Microscopic Anatomy, Biochemistry and Medicine, University of Georgia School of Medicine, Augusta

1. Heavy vascularization, thickening and opacity of the cornea were observed in 13 of 22 rats which were placed on a pantothenate-deficient diet when from 41 to 61 days of age.
2. Similar but less marked changes were seen in 11 of 23 rats placed on a pyridoxine-deficient diet when 45 to 57 days of age.
3. The changes observed were similar to those observed in early vitamin A deficiency and in deficiencies of isoleucine and of valine.

1 A preliminary report of this work has been published (Bowles, '47).

Manuscript received 23 August 1948.




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