Journal of Nutrition

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Journal of Nutrition Vol. 36 No. 6 December 1948, pp. 739-749
Copyright © 1948 by American Society for Nutrition
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Anemia and Edema of Chronic Choline Deficiency in the Rat1

Four Figures

R. W. Engel

Laboratory of Animal Nutrition, Alabama Polytechnic Institute, Auburn

Prolonged feeding of diets deficient in choline produced an anemia in rats. The hemoglobin levels in the deficient animals ranged from 6.25 to 11.95 gm per 100 ml of blood. The anemia was prevented by dietary supplements of choline chloride or DL-methionine. The sodium salt pteroyl-diglutamic acid was ineffective as a curative agent.

The prolonged feeding of diets low in protein and choline resulted in symptoms of severe nutritional edema in 7 of 12 rats. This condition was not observed in control animals receiving the same diets supplemented with choline.

1 Published with the approval of the Director, Alabama Agricultural Experiment Station, Auburn. A preliminary report of this work was made at the annual meeting of the Federation of American Societies for Experimental Biology, Federation Proceedings, Volume 7, Number 1, Part 1, p. 285, 1948.

Manuscript received 19 July 1948.




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