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Pteroylglutamic Acid Requirement of the Rat and a Characteristic Lesion Observed in the Spleen of the Deficient Animal^1,2,

Two Figures

Department of Chemistry and Nutrition, School of Tropical Medicine, San Juan, Puerto Rico

1. Twenty-one-day-old Wistar rats, fed a PGA-deficient ration containing 2% SST as inhibitor, developed marked deficiency symptoms in an average of three to 4 weeks on the ration.

2. Full remission of the depletion symptoms was obtained by administration of 5 µg of PGA 6 times per week during a period of 5 weeks.

3. Levels of PGA below this amount induced partial remission of some, or all, the symptoms at rates that were roughly proportional to the level of PGA fed to the animals.

4. A characteristic lesion, hitherto undescribed, consisting of infarction of the spleen, was observed in a high percentage of the PGA-deficient animals. No such lesion was found in animals that had received 5 µg or more of pteroylglutamic acid per day as a dietary supplement during a period of 5 weeks subsequent to depletion.

² A preliminary report of this investigation was presented by the author at the meeting of the American Federation of Biological Societies held at Atlantic City, March 15–19, 1948.

Manuscript received 12 June 1948.