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Journal of Nutrition Vol. 36 No. 3 September 1948, pp. 331-338
Copyright © 1948 by American Society for Nutrition
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Implantation in Normal and Vitamin E Deficient Rats1

Two Figures

Hans Kaunitz, Charles A. Slanetz and Ruth Ellen Johnson

Departments of Pathology and Animal Care, College of Physicians and Surgeons, Columbia University, New York City

1. The implantation rate in a highly inbred rat colony maintained on a complete, purified diet was determined until the rats were 21/2 years old.
2. The implantation rate of rats maintained on the same diet without the tocopherol supplement was found to be significantly lower than that of the control group after the rats were 9 weeks old. Tocopherol is essential for the ability of the rat to become pregnant.
3. Single doses of 1–3 mg of alpha-tocopherol administered early in life have a beneficial effect on subsequent growth, implantation rate, and life span of the female rat.

1 Aided by a grant from the John and Mary R. Markle Foundation.

Manuscript received 3 April 1948.




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