Journal of Nutrition

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Journal of Nutrition Vol. 35 No. 5 May 1948, pp. 539-548
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The Effect of Isocaloric Substitution of Alcohol for Dietary Carbohydrate upon the Excretion of B Vitamins in Man1

Roy E. Butler2 and Herbert P. Sarett

Nutrition Research Laboratory, Department of Medicine, Tulane University School of Medicine, New Orleans

The isocaloric replacement of carbohydrate (sugar and cornstarch) by ethyl alcohol in an adequate diet resulted in an increased excretion of thiamine and N1-methylnicotinamide in 2 human subjects. No significant changes were found in the excretion of creatinine, nitrogen, tryptophane, pantothenic acid and pteroylglutamic acid.

These data may suggest that the substitution of alcohol for carbohydrate has a thiamine and nicotinic acid sparing action.

The excretion of 4-pyridoxic acid on the carbohydrate diet was increased to unexplainably high levels.

1 This work was supported by grants from the Nutrition Foundation, Inc., the Williams-Waterman Fund of the Research Corporation, and the United States Public Health Service.

2 Senior Surgeon, Division of Physiology, National Institute of Health, U.S. Public Health Service.

Manuscript received 12 January 1948.




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