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The Relation of Thiamine Clearance to Blood Levels in Man

One Figure

The Nutrition Laboratory and Department of Medical Research, Medical School, University of Manitoba, Winnipeg, Canada

1. Simultaneous blood thiamine and thiamine clearance estimations were made on 23 hospital patients.

2. Low clearance values were found in the more severely debilitated subjects regardless of the etiology of their condition, while larger amounts of thiamine were excreted by convalescent subjects and those under investigation for minor ailments.

3. In the group excreting less than 90 µg thiamine, higher blood levels were found in the more severely ill patients.

4. A significant negative correlation was found between blood cellular thiamine and thiamine clearance values below 90 µg. A similar correlation of age with clearance values was considered a reflection of the general debility of the elderly subjects of the series.