Journal of Nutrition

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Journal of Nutrition Vol. 35 No. 1 January 1948, pp. 1-11
Copyright © 1948 by American Society for Nutrition
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Congenital Malformations Induced in Rats by Maternal Vitamin A Deficiency

II. Effect of Varying the Preparatory Diet Upon the Yield of Abnormal Young1

Four Figures

Josef Warkany and Carolyn B. Roth

Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio

Congenital abnormalities can be induced in the offspring of female rats reared and bred on diets deficient in vitamin A. The abnormalities are found in soft tissues and are different from those induced in the skeleton by maternal riboflavin deficiency.

Variations of the preparatory diet influence the yield of abnormal young. Increase of the carotene supplement results in an increased fertility rate, but the percentage of abnormal young decreases. Reduction of the carotene supplements reduces fertility while the percentage of abnormal young increases.

1 This work was aided in part by a grant from the Nutrition Foundation, Inc., New York.

Manuscript received 12 August 1947.




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