QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Warkany, J. Articles by Roth, C. B. Search for Related Content PubMed Articles by Warkany, J. Articles by Roth, C. B.

Congenital Malformations Induced in Rats by Maternal Vitamin A Deficiency

II. Effect of Varying the Preparatory Diet Upon the Yield of Abnormal Young¹

Four Figures

Children's Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio

Congenital abnormalities can be induced in the offspring of female rats reared and bred on diets deficient in vitamin A. The abnormalities are found in soft tissues and are different from those induced in the skeleton by maternal riboflavin deficiency.

Variations of the preparatory diet influence the yield of abnormal young. Increase of the carotene supplement results in an increased fertility rate, but the percentage of abnormal young decreases. Reduction of the carotene supplements reduces fertility while the percentage of abnormal young increases.

Manuscript received 12 August 1947.

This article has been cited by other articles:

				J. WARKANY, B. B. MONROE, and B. S. SUTHERLAND Intrauterine Growth Retardation Arch Pediatr Adolesc Med, August 1, 1961; 102(2): 249 - 279. [Abstract] [PDF]

				J. N. YAMAZAKI, S. W. WRIGHT, and P. M. WRIGHT OUTCOME OF PREGNANCY IN WOMEN EXPOSED TO THE ATOMIC BOMB IN NAGASAKI Arch Pediatr Adolesc Med, April 1, 1954; 87(4): 448 - 463. [Abstract] [PDF]

				F. C. FRASER and T. D. FAINSTAT CAUSES OF CONGENITAL DEFECTS: A Review Arch Pediatr Adolesc Med, November 1, 1951; 82(5): 593 - 603. [Abstract] [PDF]