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Journal of Nutrition Vol. 34 No. 4 October 1947, pp. 431-441
Copyright © 1947 by American Society for Nutrition
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Studies of Thyroid Toxicity

I. A Nutritional Factor Which Alleviates the Toxicity of Ingested Thyroid Substance1

Joseph J. Betheil, V. D. Wiebelhaus and Henry A. Lardy

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. The presence in yeast of an antithyrotoxic factor, which has been previously reported, has been confirmed in these studies.
2. Liver has been found to be a better source of the antithyrotoxic material than yeast. This factor is not one of the known B vitamins. It is heat stable and under the experimental conditions employed is not destroyed by autoclaving in acid or alkaline solution.
3. Calcium pantothenate and inositol did not exert an antithyrotoxic effect when fed at very high levels in a purified ration.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation.

Manuscript received 20 June 1947.




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