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Protein Assay by Rat Growth

A Comparison of (A) Litter Mates Vs. Randomly Selected Males, and (B) Moderate Restriction of Food Intake Vs. Ad Libitum Feeding

One Figure

Research Laboratories, The Arlington Chemical Company, Yonkers, New York

1. Groups of 9 or 10 randomly chosen male albino weanling rats, selected from groups of 50 or more, give mean growth response (and variance) of precisely the same order of magnitude as groups from the same stock which are paired with respect to sex and litter.

2. Preconditioning of the experimental population by feeding for 1 week on a 10% casein ration offers some improvement but does not entirely eliminate fatalities or irregular performance during subsequent weeks on test.

3. Partial restriction of food intake (to not more than 10 gm daily) reduces the mean growth response over 28 days on 10% casein rations by approximately 20% from the mean growth of ad libitum fed animals.

4. The variance for restricted fed animals is only about one-eighth to one-tenth that observed for ad libitum fed animals.

5. The reduction of variance offers approximately 3.5-fold improvement in the discriminatory capacity of an assay test set-up on a 90% criterion.

6. The physiological implications of the partial food restriction technic remain to be elucidated.