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A Study of the Fasting-Hour Excretion of Thiamine in the Urine of Normal Subjects¹

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Department of Biochemistry, Emory University, Georgia

1. The 24-hour urinary output of thiamine of 63 normal young adults was compared with that in a "fasting-hour" specimen, collected in the hour following completion of the 24-hour period and after an over-night fast. The 2 values show good over-all correlation with a coefficient of 0.70.

2. The percentage of a 1-mg oral test dose of thiamine returned in 4 hours in the fasting state was also determined in 20 of the 63 subjects. The correlation between the test dose return and the 24-hour excretion was better than that between the test dose return and the fasting-hour output. However, the procedure followed in the clearance test is open to criticism.

3. The fasting-hour excretion test offers itself as a convenient method of estimating thiamine nutritional status in survey work where a large number of individuals are to be tested.

4. The critical level of fasting-hour excretion of thiamine appears to be 4 µg. Values below this suggest a likelihood of inadequate thiamine intake.

Manuscript received 16 May 1947.