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The Nutrition of the Mouse

I. A Difference in the Riboflavin Requirements of Two Highly Inbred Strains¹

One Figure

Yale Nutrition Laboratory, Department of Physiological Chemistry, Yale University, New Haven, Connecticut

1. The riboflavin requirement of 2 highly inbred strains of mice has been studied by measuring growth rates at various dietary levels of the vitamin after a 1-week depletion period.

2. Mice of the C₅₇ strain showed maximal growth under the conditions of these experiments when the diet contained 0.4 mg of riboflavin per 100 gm, while the A strain required a dietary level of 0.6 mg.

3. At an 0.2 mg level C₅₇ mice had lowered red cell counts and muscle and liver riboflavin content, while the A strain showed no such difference.

Manuscript received 11 June 1947.