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Metabolism of Women During the Reproductive Cycle

XIII. The Utilization of Niacin During Lactation¹

Research Laboratory, Children's Fund of Michigan, Detroit

The niacin intake for 5-day periods and output in 24-hour collections of milk and urine were determined for normal multiparas during the first 10 days postpartum and at various intervals during mature milk production. The intakes of the women were comparable qualitatively but the quantity was determined by appetite. With an average daily intake of 16.5 mg of niacin the average secretion in milk per 24 hours increased from 0.04 mg on the first day postpartum to 2.94 mg on the tenth day. Excretion in the urine ranged from 0.92 to 0.98 mg.

The average volume of mature milk secreted per day during each of 17 5-day periods ranged from 268 to 1020 ml. The average daily niacin content of the milk ranged from 0.52 to 2.02 mg. From 0.35 to 1.08 mg of niacin were excreted in urine. During 10 5-day periods the average daily urinary excretion of N¹-methylnicotinamide ranged from 0.8 to 8.8 mg averaging 4.0 mg. Of the daily niacin intakes during mature milk production, averages of 7 and 3%, respectively, appeared in the milk and urine as niacin.

² Now professor, Department of Biochemistry, Cornell University, Ithaca, N. Y.

Manuscript received 27 March 1947.