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The Effect of Mixed Tocopherols on the Utilization of Vitamin A in the Rat¹

Research Laboratories, Parke, Davis and Co., Detroit, Michigan

1. Growth studies indicated that when vitamin A was fed at a daily level of 2.04 units to rats receiving a vitamin A–E free diet, the addition of tocopherols caused a further increase in weight.

2. Variable growth responses to comparable supplements of vitamin A were obtained when different types of vegetable oil were included in the U.S.P. vitamin A free diet. When the U.S.P. diet containing either olive or cottonseed oil was used, daily feeding of 0.3 mg of tocopherols increased the weight gain promoted by a vitamin A supplement but the addition of tocopherols to a corn oil diet had no effect on the growth of rats receiving vitamin A.

3. The supplementary effect of tocopherol administration on growth was apparent when vitamin A was fed at low levels but this effect gradually disappeared with an increasing intake of vitamin A.

4. Tocopherols exerted a supplementary effect on vitamin A utilization whether the vitamin A and tocopherols were given together or on separate days. A water soluble preparation of tocopherols administered by injection was also shown to increase the growth response to vitamin A.

5. The storage of vitamin A in the liver of the rat was increased when tocopherols were given with vitamin A for an extended period.

Manuscript received 6 March 1947.