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Experiments with Delayed Supplementation of Incomplete Amino Acid Mixtures¹

Four Figures

Department of Physiology, School of Medicine, University of Southern California, Los Angeles; and Van Camp Laboratories, Terminal Island

The fate of dietary amino acid mixtures which, because of absolute or relative lack of certain essential constituents, would either not be utilized or only partially utilized for protein formation was investigated.

With delayed supplementation of the lacking amino acid, it was shown that the missing tryptophane, methionine or lysine, when fed several hours after feeding of the "incomplete" mixture, does not promote growth. This finding supports the view that the "incomplete" amino acid mixtures are not stored in the body but are irreversibly further metabolized. It shows also that for protein synthesis all the essential components have to be present simultaneously.

² With the technical assistance of Leslie E. Geiger.

Manuscript received 12 February 1947.

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