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Further Studies of Manganese Deficiency in the Rabbit

U. S. Plant, Soil, and Nutrition Laboratory, Agricultural Research Administration, Ithaca, New York

Manganese deficiency in the rabbit was studied using the paired-feeding technique with a basal diet of milk.

On the unsupplemented diet there was a lowered arginase activity of the liver and a lowered "alkaline" phosphatase activity of the ulna. The latter finding is associated with impaired bone formation noted in the gross as crooked front legs. The fresh weight, percentage ash, total ash, density and length of the humerus was significantly lower in the manganese-deficient animals.

Though the food intake of the 2 groups was equalized, the controls gained more weight than those fed the low-manganese diet.

In the manganese-deficient animals the concentration of manganese in the liver and in the femur was much reduced, while that in the blood serum was not.

In other experiments in which the feed intake was not equalized, no significant differences were found for the following: "acid" or "alkaline" phosphatase activity of the blood serum, kidney, liver, or small intestine; hemoglobin concentration of the blood; inorganic phosphorus of the serum; incidence of testicular degeneration.