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The Effect of Fat Level of the Diet on General Nutrition

III. Weight Loss, Mortality and Recovery in Young Adult Rats Maintained on Restricted Calories¹

Department of Biochemistry and Nutrition, University of Southern California, School of Medicine, Los Angeles

When young adult rats are subjected to severe caloric restriction on diets varying in fat content, weight loss is less rapid, and mortality is less, on diets containing liberal amounts of fat than on a fat-free diet. During recovery from the period of caloric restriction, weight loss is more rapidly regained, and reproductive capacity is superior on diets containing fat. Reproductive capacity is still subnormal 4 to 6 weeks after transfer to ad libitum feeding, a time when body weight and physical capacity have returned to normal. The significance of the results of the present series of experiments is briefly discussed in relation to the role of fat in metabolism.

We are indebted to Merck and Co., Rahway, N. J., for the synthetic B vitamins; to the Winthrop Chemical Co., Albany, N. Y., for the crystalline vitamin D₂ and to Lederle Laboratories, Inc., Pearl River, N. Y., for the folic acid.

Manuscript received 2 January 1947.