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Journal of Nutrition Vol. 33 No. 5 May 1947, pp. 561-567
Copyright © 1947 by American Society for Nutrition
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The Role of B6-Deficiency in the Tryptophane-Niacin Relationships in Rats1

Fred Rosen2, J. W. Huff3 and W. A. Perlzweig

Department of Biochemistry, Duke University School of Medicine, Durham, N. C.

The omission of pyridoxine from the diet of rats results in a progressive decrease in the urinary excretion of N1-methylnicotinamide after doses of tryptophane. This defect is only slightly overcome by the restoration of pyridoxine to the diet. The data indicate that the abnormal formation of xanthurenic acid in B6 deficiency is not responsible for the impaired tryptophane to niacin transformation.

1 The authors wish to thank Miss Nancy Anne Hunter and Miss Betty Jean Peck for helpful technical assistance.

2 Nutrition Foundation Fellow.

3 Nutrition Foundation Fellow. Present address: Medical Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

Manuscript received 31 December 1946.




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