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The Formation of Capillaries and Other Tissue Changes in the Cornea of the Methionine-Deficient Rat

Twelve Figures

Departments of Pathology, Medicine, Biochemistry and Microanatomy, University of Georgia School of Medicine, Augusta

The development of corneal vascularization in rats fed a diet deficient in the sulfur-containing amino acids was followed with the biomicroscope. Histologic studies confirmed these observations. Vascularization was noted first in the subepithelial tissue, and when pronounced, vessels appeared in the deeper portions. Non-canalized capillaries were observed. A difference in the cellular components of the substantia propria was noted and the significance of the endothelial-like cells as to their relation with newly formed capillaries is discussed.

Degenerative changes of the epithelial cells of the cornea are described.

No histologic changes in the lenses were seen.

Manuscript received 12 October 1946.

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