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The Relationship of Nicotinic Acid, Tryptophane and Protein in the Nutrition of the Pig¹

Departments of Agricultural Chemistry, Animal Husbandry and Animal Pathology and the Institute of Nutrition, Michigan State College, East Lansing

When a high protein, low nicotinic acid, corn ration was fed to weanling pigs, mild symptoms of nicotinic acid deficiency occurred. The symptoms of nicotinic acid deficiency were confined entirely to the large intestine and particularly to the colon.

The lowering of the protein content of the same corn ration to 14.0% produced very severe inflammation in the large intestine. Supplementing this ration with 200 mg of d,l-tryptophane per day per pig gave excellent growth response in the animal. Two of the animals in this lot showed a very milk inflammatory condition of the large intestine.

No symptoms of nicotinic acid deficiency were noted when the corn was replaced with oats.

Manuscript received 27 October 1946.