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Dental Caries in the Cotton Rat

VIII. Further Studies on the Dietary Effects of Carbohydrate, Protein and Fat on the Incidence and Extent of Carious Lesions¹

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. The ingestion of diets in which starch or dextrin had been substituted for sucrose resulted in a low incidence and extent of dental caries in the cotton rat as compared with those found after ingestion of the control sucrose ration.

2. Diets in which 10 parts of lard had been added at the expense of the carbohydrate gave some protection as compared with the low fat, sucrose ration. No difference was observed in the effects of glucose, dextri-maltose, or sucrose in these lard rations.

3. With sucrose rations containing 10 parts of lard, increasing the protein level at the expense of the remaining carbohydrate further reduced the caries occurrence.

Supported in part by grants from the Nutrition Foundation, Inc., New York, and the National Dairy Council, Chicago.

We are indebted to Merck and Company, Rahway, New Jersey, for the crystalline vitamins; to Abbott Laboratories, Chicago, for the halibut liver oil; and to Wilson and Company, Chicago, for the 1 : 20 liver extract and dog food used in this study.

² Now at the Harvard School of Dental Medicine.

Manuscript received 20 May 1946.

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