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A Comparison of Riboflavin Synthesis and Excretion in Human Subjects on Synthetic and Natural Diets

New York State College of Home Economics, Cornell University, Ithaca

Three normal women were maintained for 7 weeks on a synthetic diet containing 1.09 mg of riboflavin per day. This diet was followed, after a month's respite, by a diet of natural foods containing 1.33 mg riboflavin per day. Throughout the study 24-hour urinary excretions of riboflavin were determined, and during 2 weeks of the time on the synthetic diet, 1-hour fasting excretions were also measured. Fecal riboflavin excretions were measured by 5-day periods. The results may be summarized as follows:

1. Daily urinary riboflavin values for the three subjects averaged 165, 152, and 161 µg on the synthetic diet, and 174, 229, and 210 µg on the diet of natural foods.

2. The 1-hour fasting urinary excretions of riboflavin varied from 3.7 to 10.9 µg, with average values for the three subjects of 5.9, 7.1 and 7.8 µg.

3. Urinary riboflavin excretion showed no relation to urinary volume.

4. Fecal riboflavin excretions on the diet of natural foods were 3.7 to 3.8 times greater than those obtained on the synthetic diet.

5. On the diet of natural foods, total riboflavin excretions were 2.8 times greater than on the synthetic diet for all three subjects, and for two subjects exceeded the intake.