Journal of Nutrition

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Journal of Nutrition Vol. 32 No. 1 July 1946, pp. 37-45
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Attempts to Produce a Niacin Deficiency in the Rhesus Monkey1

Three Figures

J. M. Cooperman, K. B. McCall, W. R. Ruegamer and C. A. Elvehjem

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Monkeys on a purified ration extremely low in niacin develop a deficiency which does not respond to niacin amide therapy. Whole liver powder, a good source of the monkey anti-anemia factor, causes a prompt remission of the deficiency symptoms.

When monkeys are fed a ration containing 40% corn grits, a deficiency characterized by a loss in weight, suboptimal hemoglobin, and a reversed neutrophile-lymphocyte count develops. Neither niacin, tryptophane, nor a combination of the two ameliorate the syndrome. Lyophilized liver or whole liver powder correct the deficiency.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Aided in part by grants from the National Foundation for Infantile Paralysis, Inc., New York, and Wisconsin Alumni Research Foundation.

Manuscript received 8 March 1946.




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