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The Effect of Variations in the Level of Dietary Calcium Upon the Growth of Young Rats Receiving Atabrine

Department of Nutrition, Harvard School of Public Health, and the Department of Biochemistry, Harvard Medical School, Boston, Massachusetts

conclusions

1. The inhibition of growth of young rats by the addition of 40 or 60 mg % atabrine to a purified ration was significantly greater in animals maintained on a high calcium ration, 1.35%, than when the ration contained a calcium level of 0.55% or 0.15%.

2. The average concentration of atabrine in the liver and spleen of rats on the high calcium diet was considerably greater than that found for animals receiving the low calcium diet, despite a comparable atabrine intake.

3. The concentration of atabrine in the liver in these experiments was as high at 30 days as after 63 days.

4. Animals on the high calcium diet had a more alkaline reaction in the lower small intestine and cecum. However, by the addition of various salts it could not be shown that intestinal pH was a major factor in affecting atabrine toxicity. Some animals on the high calcium diet exhibited renal calculi which may have impaired the excretion of atabrine. Hence it is not clear whether the increased toxicity of atabrine on a high calcium intake is due to increased absorption, decreased excretion, or to a specific effect of calcium on atabrine metabolism.