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The Ascorbic Acid Content of Whole Blood Plasma of Normal Rats with Evidence of a Sex Difference¹

Laboratory of Human Nutrition, School of Home Economics, University of Alabama, University, Alabama

Mature, normal rats, 50 males and 51 females, were sacrificed for determination of the ascorbic acid content of the plasma and whole blood, and of hemoglobin values.

The ascorbic acid content of the plasma of males was 0.87 ± .028 mg, and of females was 0.33 ± .019 mg per 100 ml; the difference was highly significant.

The ascorbic acid content of the whole blood of males was 0.72 ± .017 mg and of females was 0.35 ± .011 mg per 100 ml; the difference again was highly significant.

There was a significant difference in hemoglobin values for the two sexes, 13.7 ± 0.10 gm per 100 ml for males and 13.0 ± 0.12 gm for females. There was no correlation between the hemoglobin and the ascorbic acid content of the blood nor between either of these substances and the weight or age of the adult animals.

At low levels of plasma ascorbic acid the corresponding values for ascorbic acid in whole blood were higher; at plasma levels of 0.59 mg for males and 0.30 mg for females the order of the values was reversed.

Manuscript received 26 November 1945.