Journal of Nutrition

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Journal of Nutrition Vol. 31 No. 1 January 1946, pp. 67-78
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The Relation of Vitamin A Intake to Length of Life, Growth, Tooth Structure and Eye Condition

Three Figures

Henry E. Paul and Mary F. Paul

Eaton Laboratories, Inc., Norwich, New York

On a vitamin A-free diet the life span of albino rats increases with increasing vitamin A intake at levels of 1, 2, 4 and 20 U.S.P. vitamin A units per 100 gm. of body weight.

The effect of increasing vitamin A levels is reflected similarly on the four physiological criteria studied — life span, growth, tooth structure, and eye condition.

The vitamin A requirement of the albino rat estimated on the basis of maximum life span and optimal growth may be approximated at 10 U.S.P. units of vitamin A per 100 gm. of body weight. This is about five times the minimum requirement previously estimated on the basis of vaginal smear records.


Manuscript received 3 August 1945.


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ScienceHome page
K. Gruber, L. O'Brien, and R Gerstner
Vitamin A: not required for adrenal steroidogenesis in rats
Science, February 6, 1976; 191(4226): 472 - 475.
[Abstract] [PDF]




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