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Eaton Laboratories, Inc., Norwich, New York
On a vitamin A-free diet the life span of albino rats increases with increasing vitamin A intake at levels of 1, 2, 4 and 20 U.S.P. vitamin A units per 100 gm. of body weight.
The effect of increasing vitamin A levels is reflected similarly on the four physiological criteria studied life span, growth, tooth structure, and eye condition.
The vitamin A requirement of the albino rat estimated on the basis of maximum life span and optimal growth may be approximated at 10 U.S.P. units of vitamin A per 100 gm. of body weight. This is about five times the minimum requirement previously estimated on the basis of vaginal smear records.
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K. Gruber, L. O'Brien, and R Gerstner Vitamin A: not required for adrenal steroidogenesis in rats Science, February 6, 1976; 191(4226): 472 - 475. [Abstract] [PDF] |
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