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The Influence of Ascorbic Acid on the Activity of Gonadotropic Hormones in Guinea Pigs¹

Departments of Dairy and Physiology and the Institute of Nutrition, Michigan State College, East Lansing

Gonadotropin injections in vitamin C depleted females resulted in an average ovary weight 1.73 times greater than in depleted females not receiving gonadotropin injections. the addition of vitamin C further increased the gonadotropic effects and produced ovaries 1.38 times heavier than in those receiving gonadotropin alone.

The injections of 50 or 100 R.U. of gonadotropin into vitamin C depleted male guinea pigs increased the testis weight 1.81 times as compared to the depleted guinea pigs not receiving gonadotropin. Supplementing the basal diet with 50 mg. of vitamin C per day, however, did not further increase the testis weight produced by gonadotropin alone.

The augmentation of the effects and the utilization of gonadotropic hormone caused by vitamin C appears to differ with sex as well as species.

Manuscript received 25 June 1945.