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Nutritional Effects on the Gastric Mucosa of the Rat

I. Lesions of the Antrum

Five Figures

Department of Pathology, Columbia University, New York

1. Further evidence is adduced for the conclusion that in rats a rather early manifestation of calcium deficiency is found in the type of gastric lesion which occurs in the mucosa of the antrum. The changes consist of necrosis, hemorrhage and epithelial hyperplasia. Addition of phosphate accentuates the lesions, while vitamin D administration definitely reduces their number.

2. It is true, as others have found, that thiamine or total B complex deficiency will produce small lesions of the same type. However, while calcium increments in the diet abolish the lesions of thiamine deficiency, added thiamine has no preventive effect in calcium deficiency.

3. The administration of neutralizing agents as such has no effect on the lesions, indicating the improbability that gastric HCl plays a role in their formation.

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