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The Effects of Light, Trauma, Riboflavin, and Ariboflavinosis on the Production of Corneal Vascularity and on Healing of Corneal Lesions¹

Division of Nutrition and Physiology, The Public Health Research Institute of The City of New York, Inc., New York

1. Brilliant continuous illumination with incandescent lamps did not augment the changes in the cornea and conjunctiva resulting from riboflavin deficiency.

2. The healing of injury of the cornea resulting from ultraviolet light was handicapped by brilliant continuous illumination from incandescent lamps and by protracted riboflavin deficiency. However, the failure to observed an effect of either visible or ultraviolet light on the riboflavin content of the cornea indicates that this handicap is not the result of local destruction of riboflavin by light but due to some other cause. The healing of injury due to milder trauma, that involving primarily the epithelium, was not affected by either light or riboflavin deficiency alone under the conditions of these experiments. However, a combination of these two factors did lead to definite handicaps.

3. High riboflavin intake failed to prevent the occurrence of "spontaneous corneal vascularity" occurring in a normally nourished rat colony.

4. The variety of agents and deficiencies which will induce corneal vascularization indicates the need for caution in interpretation of corneal vascularization in man.

Manuscript received 4 June 1945.