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Goiter Studies with the Rat¹

One Plate (Six Figures)

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

A ration is reported which will produce an iodine deficiency in the white rat. Definite enlargement, redness, and histological changes were noted in the thyroid glands of the rats on the basal ration and on the basal plus 0.5 µg. of iodine per rat per day. The addition of 1.0 and 2.0 µg. of iodine per day to the basal ration largely corrected the glandular enlargement. The pathological changes in the thyroids were partially prevented by 1.0 µg. of iodine per day; however, 2.0 µg. resulted in almost complete prevention of pathological changes. No differences in growth or food consumption were noted between the basal group and the groups on the iodine supplements.

The work was supported in part by a grant from the Wisconsin Alumni Research Foundation.

Manuscript received 11 April 1945.