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A Study of Hemoglobin Formation Following the Administration of Certain Amino Acids to Rats Fed a Diet Low in Protein¹

Department of Physiological Chemistry, Wayne University College of Medicine, Detroit

The effects of the administration of various individual amino acids on the hemoglobin content of the blood of rats made anemic by the ingestion of a diet low in protein have been studied.

No consistent, sustained increase in hemoglobin values occurred following supplementation with any of the ten "essential" amino acids or with glycine, cystine, glutamic acid, proline, or tyrosine.

These results are interpreted as evidence that no single amino acid can be regarded as a "key" amino acid in hemoglobin synthesis in the organism but rather that a combination of amino acids in as yet undetermined proportions is essential for the in vivo fabrication of the hemoglobin molecule.

Manuscript received 30 April 1945.