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The Effects of Radiant Energy on Hemorrhagic Anemia^*

(From the Laboratory of Physiology, School of Medicine, Tulane University of Louisiana, New Orleans.)

Anemia was produced in 24 dogs employing the procedure and diet elaborated by Whipple and Robscheit-Robbins. Carbon and mercury arc irradiation of these animals results in marked and persistent increases in the number of erythrocytes and reticulocytes, the responses being more marked with massive exposures than with smaller doses repeated more often.

An increase in hemoglobin regeneration was noted in only one experiment. In twelve cases the amount of hemoglobin formed during and immediately following the irradiation period is much less than in previous control periods; in the remaining eleven experiments there was no change in the amount formed. The absence in such radiation of any marked stimulus to hemoglobin formation is evidenced by the fact that peaches, apricots, or lettuce added to the diet of animals which had shown no response to radiation, produce their typical influence. The acceleration of hemoglobin regeneration produced by adding these substances to the diet is also not demonstrably influenced by any dosage of radiant energy as emitted from either of the sources used.

It is a pleasant duty we do in recording here our thanks to Miss Irene M. Sellier for the faithful and painstaking way in which she has aided us in collecting and recording the data which are the basis of these papers.

Manuscript received 31 May 1930.