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Blood Studies in Hemorrhagic Anemia^*

(From the Laboratory of Physiology, School of Medicine, Tulane University of Louisiana, New Orleans.)

A study is presented of the blood cytology in severe secondary anemia produced and maintained for varying lengths of time in twenty-seven dogs following the method of Whipple and Robscheit-Robbins. In dogs fed the standard bread S there is an average weekly production of 4 gms. over and above the maintenance level. When apricots are added this becomes 15 gms., when lettuce 10 gms. and when peaches 7 gms. Cowgill's diet was found to be inadequate for maintaining a constant hemoglobin level under similar conditions.

After several weeks of bread S feeding, there is a gradual increase in red cell number accompanied by a decrease in the corpuscular volume and corpuscular hemoglobin. The percentage of hemoglobin in these smaller cells, however, remains relatively unchanged. If lettuce, apricots or peaches are added to the diet, these changes to do not occur and they are interpreted as being compensatory reactions to the oxygen deficiency occasioned by the low hemoglobin when the severe anemic level is maintained.

Manuscript received 31 May 1930.