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Journal of Nutrition Vol. 29 No. 5 May 1945, pp. 361-363
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The Effect of Atabrine on Thiamine Deficiency in the Young Rat1

One Figure

D. M. Hegsted, J. M. McKibbin and F. J. Stare

Department of Nutrition, Harvard School of Public Health, and the Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts

The addition of atabrine to a thiamine deficient diet for rats delays loss of weight, onset of symptoms, and death. Low levels of thiamine produce greater gains in animals receiving atabrine than in controls. Atabrine thus has a "thiamine sparing" action.

1 The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and Harvard University.

Manuscript received 31 January 1945.




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