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Mitotic Activity and Wound Healing in the Corneal Epithelium of Vitamin A Deficient Rats¹

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Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital Baltimore, Maryland

1. The mitotic activity and the cell movements in wound healing have been examined in the corneal epithelium of vitamin A deficient rats.

2. The overall mitotic rate per 1000 basal cells was found to be reduced by about 30% in vitamin A deficiency.

3. The speed of the mitotic cycle was likewise found to be similarly reduced.

4. The epithelial cells in some vitamin A deficient animals were found to be considerably enlarged in their horizontal diameters. Consequently the inhibition of mitosis cannot be attributed to a failure in the growth of the individual cells.

5. The post-traumatic cell movements in the healing of small wounds in the corneal epithelium were not found to be significantly delayed.

Manuscript received 24 November 1944.